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Molecular Biology
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Epigenetics Tools
Phospho Specific Antibodies
Anti-DNA PKcs (phospho S2056) antibody
Anti-DNA PKcs (phospho S2056) antibody from Abcam
Be the first to write a review!
Citations:
(176)
Supplier Page
Supplier Page from
Abcam for
Anti-DNA PKcs (phospho S2056) antibody
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
Anti-DNA PKcs (phospho S2056) antibody
Company
Abcam
Price
Pricing Info
Supplier Page
View Company Product Page
Catalog Number
ab18192
Antibody Type
Primary
Isotype
IgG
Quantity
100 UG
Applications
ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Western blot
Clonality
Polyclonal
Host
Rabbit
Conjugate/Tag
Unconjugated
Concentration
0.2 mg/ml
Modifications
Phospho-S2056
Gene Name
PRKDC
Reactivity
Human
Target
DNA PKcs
Add to Compare List
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB2 0AX
United Kingdom
Phone
: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600
Company Profile
Website:
http://www.abcam.com
Citations (176)
(1)
Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction
Nucleic Acids Research
November 27, 2023
Antonia Kefala Stavridi, Amandine Gontier, Vincent Morin, Philippe Frit, Virginie Ropars, Nadia Barboule, Carine Racca, Sagun Jonchhe, Michael J Morten, Jessica Andreani,
et al.
Bethyl Laboratories
or A199957, Abclonal), anti-
LIG4
(
A11432
,
Abclonal
), anti-DNA-PKcs PhSer-2056 (
ab18192
),
anti-PAXX
(
ab126353
) (
Abcam
) and anti-γH2AX (Cell Signaling Technologies); Peroxidase-conjugated
goat
(2)
DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining
Nucleic Acids Research
August 25, 2023
PamelaSara E Head, Priya Kapoor-Vazirani, Nagaraju P Nagaraju, Hui Zhang, Sandip K Rath, Nho C Luong, Ramona Haji-Seyed-Javadi, Fatmata Sesay, Shi-Ya Wang, Duc M Duong,
et al.
in 5% BSA and immunostained with anti-γH2AX (
Millipore
05–636
), DNA-PKcs phosphoserine 2056 (
Abcam
,
ab18192
), anti-FLAG (
Cell Signaling
:
2368P
), Artemis pS516 (
Abcam
,
ab138411
) or
XRCC4
pS260 (
Sigma
,
HPA006801
)
(3)
AMPK/FOXO3a Pathway Increases Activity and/or Expression of ATM, DNA-PKcs, Src, EGFR, PDK1, and SOD2 and Induces Radioresistance under Nutrient Starvation
International journal of molecular sciences
August 15, 2023
Urushihara Y, Hashimoto T, Fujishima Y, Hosoi Y.
(#
sc-9051
,
Santa Cruz Biotechnology, Inc
., Dallas, TX, USA); phospho-DNA-PKcs (Ser2056) antibody (#
ab18192
,
Abcam, PLC
, Cambridge, UK); EGFR antibody (#
2232
,
CST
); phospho-EGFR (Tyr845) antibody (#
2231
,
CST
);
(4)
Establishment and Characterization of Multi-Drug Resistant p53-Negative Osteosarcoma SaOS-2 Subline
Diagnostics (Basel, Switzerland)
August 11, 2023
Boichuk S, Bikinieva F, Valeeva E, Dunaev P, Vasileva M, Kopnin P, Mikheeva E, Ivoilova T, Mustafin I, Galembikova A.
Piscataway, NJ, USA); p-ATM S1981 (cat. no.
ab81292
), ATM (cat. no.
ab32420
), p-DNA-PK S2056 (cat. no.
ab18192
), DNA-PK (cat. no.
ab32566
),
MGMT
(cat. no.
ab108630
), (
Abcam plc
., Cambridge, UK); pChk1 S317 (cat.
(5)
ATR inhibition augments the efficacy of lurbinectedin in small-cell lung cancer
EMBO molecular medicine
August 7, 2023
Schultz CW, Zhang Y, Elmeskini R, Zimmermann A, Fu H, Murai Y, Wangsa D, Kumar S, Takahashi N, Atkinson D,
et al
.
(
Cell Signaling
#
2873
), pCHK2(T68) (
Cell Signaling
#
2197
),
CHK2
(
Cell Signaling
#
6334
), pDNA‐PK(S2056) (
Abcam
#
ab18192
), DNA‐PK (
Abcam
#
ab32566
), vinculin (
Sigma‐Aldrich
#
V9131
),
histone H3
(
Sigma‐Aldrich
#
07‐690
), and
(6)
Replication Protein A1 is essential for DNA damage repair during mammalian oogenesis
bioRxiv
July 10, 2023
Xiaosu Miao, Rui Guo, Andrea Williams, Catherine Lee, Jun Ma, P. Jeremy Wang, Wei Cui
(similar results, images not shown); pATR (T1989), Abcam, ab289363; DNA-PK (phospho S2056),
Abcam
,
ab18192
; p-
P53
(Ser15),
Cell Signaling
,
9284
; acetyl-
P53
(Lys379),
Cell Signaling
,
2570
;
RPA1
,
Thermo Fisher
,
(7)
Topoisomerase I Inhibition Radiosensitizing Hepatocellular Carcinoma by RNF144A-mediated DNA-PKcs Ubiquitination and Natural Killer Cell Cytotoxicity
Journal of clinical and translational hepatology
June 28, 2023
Tsai CL, Yang PS, Hsu FM, Cheng AL, Yu WN, Cheng JC.
USA), anti-
RNF144A
(
sc 393432
),
1:200
(
Santa Cruz Biotechnology
, CA, USA), or anti-phospho-
DNA-PKcs
(
ab18192
),
1:600
(
Abcam
, Cambridge, UK) for 2 h at room temperature in the dark, washed with PBS, and mounted
(8)
PAXX binding to the NHEJ machinery explains functional redundancy with XLF
Science Advances
June 2, 2023
Murielle Seif-El-Dahan, Antonia Kefala-Stavridi, Philippe Frit, Steven W. Hardwick, Dima Y. Chirgadze, Taiana Maia De Oliviera, Sébastien Britton, Nadia Barboule, Madeleine Bossaert, Arun Prasad Pandurangan,
et al.
(
A300-730A
,
Bethyl Laboratories
, or A199957, Abclonal), anti-
LIG4
(
A11432
,
Abclonal
), anti-DNA-PKcs PhS2056 (
ab18192
),
KAP-1
(
ab10483
),
anti-PAXX
(
ab126353
) (
Abcam
), and anti-γH2AX (Cell Signaling Technologies); peroxidase-conjugated
(9)
PKCδ regulates chromatin remodeling and DNA repair through SIRT6
bioRxiv : the preprint server for biology
May 24, 2023
Affandi T, Haas A, Ohm AM, Wright GM, Black JC, Reyland ME.
anti-γH2AX (Cat #
05-636
, RRID:AB_309864,
Millipore
, Burlington, MA),
1:200
anti-DNA-PK pSer2056 (Cat #
ab18192
, RRID:AB_869495,
Abcam
, Cambridge, United Kingdom), or anti-Rad51 (Cat #
ABE257
, RRID:AB_10850319,
Millipore
),
(10)
DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma
The EMBO journal
April 3, 2023
Taffoni C, Marines J, Chamma H, Guha S, Saccas M, Bouzid A, Valadao AC, Maghe C, Jardine J, Park MK,
et al
.
Primary antibodies used include: anti‐pDNA‐PKcs Ser2056 (
ab124918
,
Abcam
), anti‐pDNA‐PKcs Ser2056 (
ab18192
,
Abcam
) for
mouse
cell lines, anti‐DNA‐PKcs (
A300‐517AT
,
Bethyl
,
1:500
), anti‐DNA‐PKcs (
ab32566
,
Abcam
)
(11)
ATM Regulation of the Cohesin Complex Is Required for Repression of DNA Replication and Transcription in the Vicinity of DNA Double-Strand Breaks
Molecular cancer research : MCR
March 1, 2023
Bass TE, Fleenor DE, Burrell PE, Kastan MB.
T68 (
1:1,000
;
Cell Signaling
,
2661
), DNAPK (
1:1,000
;
Abcam
,
ab70250
), pDNAPK S2056 (
1:1,000
;
Abcam
,
ab18192
), CHK1 (
1:1,000
, Epitomics, 2865–1), pCHK1 S345 (
1:1,000
, Epitomics, S0660).
For immunoblotting
proteins
(12)
Molecular Background of Toxic-Substances-Induced Morphological Alterations in the Umbilical Cord Vessels and Fetal Red Blood Cells
International journal of molecular sciences
November 24, 2022
Zahorán S, Márton Á, Dugmonits K, Chakraborty P, Khamit A, Hegyi P, Orvos H, Hermesz E.
(DAPI)",-,-,
1:1000
,
Sigma-Aldrich
,D9542
Anti-4-hydroxynonenal
,
mouse
,mono,
1:100
,
Abcam
,
ab48506
Anti-cleaved caspase-3
,rabbit,poly,
1:100
,
Abcam
,
ab2302
Anti-DNA PKcs (phospho S2056
),rabbit,poly,
1:100
,
Abcam
,
ab18192
Anti-phospho-Histone H2A.X (Ser139),
mouse
,mono,
1:100
,
Sigma-Aldrich
,
05636i
Anti-CD235a (Glycophorin A
(13)
Spatio-temporal analysis of prostate tumors in situ suggests pre-existence of treatment-resistant clones
Nature communications
September 17, 2022
Marklund M, Schultz N, Friedrich S, Berglund E, Tarish F, Tanoglidi A, Liu Y, Bergenstråhle L, Erickson A, Helleday T,
et al
.
SCBT,
1:500
), Ku70 antibody: (E-5, Cat. # sc-17789, SCBT,
1:500
), phosphorylated DNA-PKcs:(S2056, Cat#
ab18192
,
Abcam
,
1:750
). Secondary antibodies used were
donkey anti-Rabbit IgG (H + L) Highly Cross-Adsorbed, Alexa Fluor™ 555
(14)
Mutation in senataxin alters the mechanism of R-loop resolution in amyotrophic lateral sclerosis 4
Brain : a journal of neurology
September 14, 2022
Kannan A, Cuartas J, Gangwani P, Branzei D, Gangwani L.
LG-C61),32,35 α-tubulin (#
T8203
) from
Sigma-Aldrich
, γH2AX (phospho Ser139) (
ab26350
), p-DNA-PKcs (Ser2056) (
ab18192
) and
SETX
(
ab220827
), total-DNA-PKcs (
ab53701
) from
Abcam
,
GFP
(
A11122
) from
ThermoFisher
and α-tubulin
(15)
Inhibition of Mtorc1/2 and DNA-PK via CC-115 Synergizes with Carboplatin and Paclitaxel in Lung Squamous Cell Carcinoma
Molecular cancer therapeutics
September 6, 2022
Castellano GM, Zeeshan S, Garbuzenko OB, Sabaawy HE, Malhotra J, Minko T, Pine SR.
anti-Vinculin (
Santa Cruz
SC-73614
), anti-DNA-PKcs (
Santa Cruz
SC-5282
), anti-P-S2056-
DNA-PKcs
(
Abcam
ab18192
), anti-
AKT1
(Cell Signaling Technology (
CST
) #
2938
), anti-P-S473-
AKT
(
CST
#
4060
), anti-P-Th308-
AKT
(
CST
(16)
Targeting HER3-dependent activation of nuclear AKT improves radiotherapy of non-small cell lung cancer
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
September 1, 2022
Toulany M, Iida M, Lettau K, Coan JP, Rebholz S, Khozooei S, Harari PM, Wheeler DL.
Santa Cruz Biotechnology
. Antibodies against EGFR (Cat.#
ab52894
), Lamin A/C (Cat.#
ab40567
), P-DNA-PKcs(S2056) (Cat.#
ab18192
), and DNA-PKcs (Cat.#
ab1832
) were purchased from
Abcam
. siRNA against EGFR (Cat.#L-003114),
HER2
(Cat.#L-003126)
(17)
Tyro3 Targeting as a Radiosensitizing Strategy in Bladder Cancer through Cell Cycle Dysregulation
International journal of molecular sciences
August 4, 2022
Silina L, Dufour F, Rapinat A, Reyes C, Gentien D, Maksut F, Radvanyi F, Verrelle P, Bernard-Pierrot I, Mégnin-Chanet F.
(Thr68)–(2197), DNA-PKc (4602), MERTK (4319),
TYRO3
(5585). Antibody against phospho-DNA PKc (Ser2056) (
ab18192
) was purchased from
Abcam
(Paris, France). 4.10. Statistical Analysis All functional experiments were
(18)
TDP1-independent pathways in the process and repair of TOP1-induced DNA damage
Nature communications
July 22, 2022
Zhang H, Xiong Y, Su D, Wang C, Srivastava M, Tang M, Feng X, Huang M, Chen Z, Chen J.
MABE1084
;
Millipore
;
1: 1000
dilution), dsDNA (
ab27156
;
Abcam
;
1: 5000
dilution), phospho-DNA-PKcs (S2056,
ab18192
;
Abcam
;
1: 1000
dilution), phospho-
KAP1
(S824,
4127
S;
Cell Signaling Technology
;
1: 2000
dilution),
(19)
SENP3-mediated TIP60 deSUMOylation is required for DNA-PKcs activity and DNA damage repair
MedComm (2020)
June 1, 2022
Han Y, Huang X, Cao X, Li Y, Gao L, Jia J, Li G, Guo H, Liu X, Zhao H,
et al
.
anti‐
SENP3
(
ab124790
,
Abcam
), anti‐DNA‐PKcs (
ab32556
,
Abcam
), anti‐DNA‐PKcs pT2609 (
ab97611
) and pS2056 (
ab18192
) (both
Abcam
), anti‐ATM (
sc‐135663
,
Santa Cruz Biotechnology
), anti‐ATM pS1981 (
ab81292
,
Abcam
), anti‐HA
(20)
Black Phosphorus Quantum Dots Enhance the Radiosensitivity of Human Renal Cell Carcinoma Cells through Inhibition of DNA-PKcs Kinase
Cells
May 16, 2022
Yue Lang, Xin Tian, Hai-Yue Dong, Xiang-Xiang Zhang, Lan Yu, Ming Li, Meng-Meng Gu, Dexuan Gao, Zeng-Fu Shang
for Western blotting
were: Cleaved
PARP
(
CST
,
5625
,
1:1000
), Actin (Beyotime, AA128,
1:1000
), DNA-PKcs-ps2056 (
Abcam
,
ab18192
,
1:1000
), DNA-PKcs (
Abcam
,
ab32566
,
1:1000
),
Chk2
-pT68 (
CST
,
2661S
,
1:1000
), and
Chk2
(
CST
,
2662S
,
1:1000
). 2.2.
Page
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Anti-DNA PKcs (phospho S2056) antibody from Abcam
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